Updated Methanosarcina barkeri reconstruction
In collaboration with Bill Metcalf’s lab at the University of Illinois at Urbana-Champaign, we are sequencing 20 novel Methanosarcina strains. The genomes are being analyzed to learn more about the evolution of metabolic and regulatory networks to identify environmental patterns in their evolution. As part of this analysis, we have updated the genome scale metabolic model of Methanosarcina barkeri Fusaro, a model archaeon. Along with our model of M. acetivorans, this updated model serves as a platform to enhance our understanding of methanogen metabolism, a vital part of the global carbon cycle.